Surgical Sealants and Adhesives Market By Product Type (Natural Sealants & Adhesives [Fibrin-based Sealants; Collagen-based Sealants; Albumin-based Sealants]; Synthetic & Semi-Synthetic Sealants & Adhesives [Polyethylene Glycol (PEG)-based Sealants; Cyanoacrylate-based Adhesives; Polyurethane-based Sealants]); By Indication (Surgical Hemostasis; Tissue Sealing; Tissue Engineering); By Application (General Surgery; Cardiovascular Surgery; Orthopedic Surgery; Neurological Surgery; Pulmonary Surgery; Urological Surgery; Cosmetic & Reconstructive Surgery; Others); By End-User (Hospitals; Ambulatory Surgical Centers [ASCs]; Specialty Clinics); By Geography, Segment Revenue Estimation, Forecast, 2024–2032.

Surgical Sealants And Adhesives Market Size & Overview

The Surgical Sealants and Adhesives Market was valued at $2.7 billion in 2024 and is projected to reach $4.6 billion by 2030, growing at a CAGR of 8.2% during the forecast period. The market is driven by the increasing number of surgical procedures, rising demand for minimally invasive surgeries (MIS), and advancements in biocompatible and bioabsorbable adhesives.

 

According to the World Health Organization (WHO), over 313 million surgical procedures are performed worldwide annually, with a significant percentage requiring effective wound closure and hemostatic solutions. The Centers for Disease Control & Prevention (CDC) reports that surgical site infections (SSIs) occur in 2%–5% of all surgeries, increasing the need for advanced surgical sealants to reduce complications & enhance patient recovery. Additionally, cardiovascular, orthopedic, general & trauma surgeries are major contributors to the market’s growth. The development of synthetic, fibrin-based & polyethylene glycol (PEG)-based sealants is improving hemostasis, tissue sealing, and leakage prevention across various surgical specialties. However, high costs, stringent regulatory approvals, and limited adoption in developing regions may pose challenges. Despite these hurdles, the growing healthcare investments, increasing adoption of biomaterials & rising focus on precision surgery are expected to drive market expansion in the coming years.

 

Surgical Sealants And Adhesives Market Dynamics:

Market Drivers

Rising Number of Surgical Procedures

With an aging global population & an increasing prevalence of chronic diseases, the number of surgical procedures is rapidly rising. According to the World Health Organization (WHO), an estimated 313 million surgical procedures are performed globally each year, creating a strong demand for surgical sealants and adhesives that reduce complications and improve wound healing. These products play a critical role in minimally invasive surgeries (MIS) by reducing blood loss, preventing leaks & expediting recovery times.

Advancements in Biocompatible & Synthetic Adhesives

The development of next-generation bio-based & synthetic adhesives has significantly improved patient outcomes. Cyanoacrylate-based adhesives such as Dermabond™ (Ethicon, Johnson & Johnson) provide superior wound closure compared to traditional sutures. The increasing adoption of fibrin-based and polyethylene glycol (PEG)-based sealants in cardiovascular and neurological surgeries has further propelled market growth, ensuring better tissue adhesion, reduced infection rates, and faster recovery.

 

Market Restraints

High Cost of Advanced Sealants & Adhesives

Despite their advantages, surgical sealants & adhesives are significantly more expensive than conventional sutures & staples. The average cost of fibrin-based sealants ranges between $200 - $500 per application, making it a cost-intensive solution for hospitals, especially in developing economies. The affordability challenge limits widespread adoption, particularly in regions with budget constraints & inadequate healthcare reimbursement policies.

Stringent Regulatory Approvals & Product Recalls

Regulatory hurdles are a significant barrier to market expansion. Surgical adhesives must meet strict FDA & CE approval requirements to ensure safety & efficacy. In 2023, the FDA issued a recall on certain batches of synthetic surgical adhesives due to concerns about biocompatibility & patient reactions. The lengthy approval process & the risk of post-market withdrawals pose challenges for manufacturers looking to launch innovative products.

 

Market Opportunities

Increasing Demand for Biodegradable & Natural Sealants

The growing preference for biodegradable & naturally derived sealants, such as fibrin, collagen, and albumin-based adhesives, is creating new opportunities. These sealants eliminate the need for removal post-surgery and enhance tissue regeneration. Companies such as Baxter International and CryoLife are investing in next-generation hemostatic agents to cater to the increasing demand for bioabsorbable solutions that minimize post-operative complications.

Expansion in Emerging Markets with Growing Healthcare Investments

Rapid economic growth in Asia-Pacific, Latin America, and the Middle East is leading to increased healthcare spending and infrastructure development. According to the World Bank, healthcare expenditures in India and China have grown by over 8% annually, presenting significant opportunities for surgical adhesive manufacturers. Leading players are expanding their presence in these regions through strategic partnerships, acquisitions, and product launches to capitalize on the growing patient pool and rising adoption of advanced surgical technologies.

 

Surgical Sealants And Adhesives Market Segmentation: A Comprehensive Overview

By Product Type

• Natural Sealants & Adhesives

• Fibrin-based Sealants

• Collagen-based Sealants

• Albumin-based Sealants

• Synthetic & Semi-Synthetic Sealants & Adhesives

• Polyethylene Glycol (PEG)-based Sealants

• Cyanoacrylate-based Adhesives

• Polyurethane-based Sealants

 

By Indication

• Surgical Hemostasis

• Tissue Sealing

• Tissue Engineering

 

By Application

• General Surgery

• Cardiovascular Surgery

• Orthopedic Surgery

• Neurological Surgery

• Pulmonary Surgery

• Urological Surgery

• Cosmetic & Reconstructive Surgery

• Others

 

By End-User

• Hospitals

• Ambulatory Surgical Centers (ASCs)

• Specialty Clinics

 

By Region

• North America

• Europe

• Asia-Pacific

• Latin America

• Middle East & Africa

 

Surgical Sealants And Adhesives Market Segment Analysis: Growth Trends Across Categories

By Product Type:

Leading Segment: Synthetic & Semi-Synthetic Sealants & Adhesives

Synthetic & semi-synthetic sealants and adhesives lead the surgical sealants and adhesives market due to their versatility and performance across various surgical procedures. Products such as cyanoacrylate-based adhesives and polyethylene glycol (PEG)-based sealants are in high demand because they offer fast bonding, strong adhesion, and minimal tissue reaction, making them suitable for diverse applications. This segment holds approximately 65% of the total market share. The increasing number of surgeries and the demand for effective solutions in tissue bonding and hemostasis contribute to the dominance of this segment. For example, cyanoacrylate-based adhesives are commonly used in skin closure and wound healing.

Fastest-Growing Segment: Natural/Biological Sealants & Adhesives

The fastest-growing segment is Natural/Biological Sealants & Adhesives, with a CAGR of 8% from 2023 - 2030. Fibrin-based and collagen-based sealants are experiencing high growth, particularly driven by the increasing preference for biocompatible and bioresorbable materials. This segment is favored in surgical fields like cardiovascular surgery, where natural adhesives are used to enhance tissue healing & minimize immune response. Rising awareness of the benefits of biologically derived materials is accelerating this trend.

 

By Indication:

Leading Segment: Tissue Sealing

Tissue sealing is the leading indication segment in the surgical sealants and adhesives market, holding a market share of 45%. Sealants in this category are crucial for closing incisions or wounds during surgeries, especially in procedures involving sensitive or delicate tissues. Their importance in reducing surgical complications, such as leaks and infections, contributes to the high demand for tissue sealing agents across various surgeries like cardiac, orthopedic, and gastrointestinal surgeries.

Fastest-Growing Segment: Tissue Engineering

The tissue engineering segment is growing rapidly with a CAGR of 10%, driven by advancements in regenerative medicine & the increasing need for biocompatible and functional materials that promote tissue regeneration and healing. These sealants are used in complex surgeries, including organ transplants and reconstructive surgeries, to support the formation of new tissues.

 

By Application:

Leading Segment: Cardiovascular Surgery

Cardiovascular surgery is the largest application segment for surgical sealants & adhesives, holding 30% of the market share. The demand for effective hemostasis and tissue sealing in procedures like coronary artery bypass grafting (CABG), valve repair, and heart transplants fuels the growth of this segment. Biological adhesives and sealants, such as fibrin-based products, are widely used in cardiovascular surgeries due to their compatibility with vascular tissues & their ability to reduce bleeding.

Fastest-Growing Segment: Cosmetic & Reconstructive Surgery

The cosmetic and reconstructive surgery segment is the fastest-growing, with a CAGR of 9%. This growth is driven by the increasing popularity of cosmetic procedures & the rising demand for minimally invasive surgeries that require precise tissue sealing & adhesion. Biological sealants & synthetic adhesives are preferred in these procedures for their aesthetic outcomes and safety profile.

 

By End-User:

Leading Segment: Hospitals

Hospitals remain the leading end-user segment in the surgical sealants and adhesives market, accounting for 55% of the market share. Hospitals conduct the majority of surgeries, including complex and high-risk operations, which require advanced sealants and adhesives for effective tissue closure and hemostasis. The growing number of surgeries in hospitals worldwide, especially in emerging economies, is driving the high demand for surgical adhesives in this setting.

Fastest-Growing Segment: Ambulatory Surgical Centers (ASCs)

Ambulatory surgical centers (ASCs) are the fastest-growing end-user segment, with a CAGR of 7.5%. The rise in outpatient surgeries, where patients undergo procedures & are discharged on the same day, is fueling this growth. The demand for fast-acting, safe & reliable adhesives for smaller procedures is increasing in ASCs, contributing to their rapid market expansion.

 

By Region:

Leading Region: North America

North America leads the surgical sealants and adhesives market, with a market share of approximately 40%. The region benefits from advanced healthcare infrastructure, high surgical volumes & significant investments in medical technology. The U.S., in particular, is a major consumer of surgical sealants due to its well-established healthcare systems and the prevalence of surgeries in various specialties such as cardiovascular, orthopedic, and neurological surgeries.

Fastest-Growing Region: Asia-Pacific

The APAC region is the fastest-growing in the surgical sealants and adhesives market, with a CAGR of 8.5%. Rapidly growing healthcare infrastructure, an increase in surgical procedures & the rising prevalence of chronic diseases are driving the demand for surgical sealants in this region. Countries like China & India are expected to see substantial growth in the usage of surgical adhesives, fueled by expanding healthcare access & government initiatives to improve medical standards.

 

Surgical Sealants and Adhesives Market Report Coverage

Report Attribute	Details
Forecast Period	2024 – 2032
Market Size Value in 2024	USD 2.7 Billion
Revenue Forecast in 2030	USD 4.6 Billion
Overall Growth Rate	CAGR of 8.2% (2024 – 2030)
Base Year for Estimation	2024
Historical Data	2017 – 2021
Unit	USD Billion, CAGR (2024 – 2030)
Segmentation	By Product Type, By Indication, By Application, By End-User, By Geography
By Product Type	Natural Sealants & Adhesives (Fibrin-based Sealants; Collagen-based Sealants; Albumin-based Sealants); Synthetic & Semi-Synthetic Sealants & Adhesives (Polyethylene Glycol (PEG)-based Sealants; Cyanoacrylate-based Adhesives; Polyurethane-based Sealants)
By Indication	Surgical Hemostasis; Tissue Sealing; Tissue Engineering
By Application	General Surgery; Cardiovascular Surgery; Orthopedic Surgery; Neurological Surgery; Pulmonary Surgery; Urological Surgery; Cosmetic & Reconstructive Surgery; Others
By End-User	Hospitals; Ambulatory Surgical Centers (ASCs); Specialty Clinics
By Region	North America, Europe, Asia-Pacific, Latin America, Middle East & Africa
Country Scope	US, Canada, Germany, China, India, etc.
Market Drivers	Rising surgical procedures, increasing preference for minimally invasive surgeries, advancements in bio-based adhesives
Pricing and Purchase Options	Customized options available

 

Key Players in the Surgical Sealants And Adhesives Market

• Baxter International Inc.

• Johnson & Johnson (Ethicon, Inc.)

• Braun Melsungen AG

• Medtronic plc

• CryoLife, Inc.

• Integra LifeSciences Holdings Corporation

• Tissuemed Ltd.

• Adhezion Biomedical LLC

• Cohera Medical, Inc.

• C.R. Bard (a subsidiary of Becton, Dickinson and Company)

 

Recent Developments

• In January 2023, a collaboration between Boston Children's Hospital, MIT, and Harvard-affiliated Brigham and Women's Hospital led to the development of a hydrophobic light-activated adhesive (HLAA). Inspired by natural adhesives from organisms like slugs and sandcastle worms, HLAA sets in seconds upon exposure to ultraviolet light and has been used experimentally to repair heart defects in animal models. This biocompatible, biodegradable adhesive offers a promising alternative to traditional sutures and staples, particularly in dynamic and wet environments such as cardiac tissues. 

• In December 2021, Becton Dickinson (BD) expanded its surgical offerings by acquiring Tissuemed Ltd., a UK-based medical device company known for its TissuePatch surgical sealant films. These innovative sealant films are designed to prevent leaks during surgeries, including thoracic, general, and neurosurgical procedures, by forming a covalent bond with tissue proteins. This acquisition enables BD to enhance its surgical solutions portfolio and address the growing demand for advanced sealant technologies.

• In April 2020, researchers developed a photochemically crosslinked gelatin-based tissue sealant that demonstrated high adhesive strength, elasticity, and tensile strength. This sealant effectively sealed lung, vascular & gastrointestinal defects, offering minimal inflammation & promoting good wound healing. Such advancements highlight the ongoing innovation in surgical adhesives, providing surgeons with more effective tools for tissue repair.

 

Future Outlook

The future outlook for the Surgical Sealants and Adhesives Market remains highly promising, driven by the increasing global demand for minimally invasive surgeries (MIS), advancements in biodegradable and bioengineered adhesives, and the rising burden of surgical complications such as hemorrhage and leaks. The market is expected to benefit from continuous R&D investments in next-generation tissue adhesives, including photoactivated, hemostatic, and hybrid polymer-based sealants that offer improved efficacy, faster healing, and reduced infection risks. Additionally, the integration of nanotechnology & regenerative medicine in surgical adhesives is expected to enhance their performance in wound healing and tissue regeneration. The adoption of robot-assisted surgeries and 3D-printed biomaterials is also anticipated to create new growth avenues. Emerging economies in Asia-Pacific, Latin America & the Middle East are projected to witness rapid market expansion due to rising healthcare expenditures, increasing surgical volumes, and improving medical infrastructure. However, high costs, stringent regulatory approvals, and competition from conventional sutures and staples may pose challenges to widespread adoption. Despite these hurdles, the shift toward bioabsorbable and personalized adhesive solutions, coupled with strategic mergers & acquisitions among key market players, is expected to drive the Surgical Sealants and Adhesives Market toward significant growth in the coming years.